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Early evidence of SANS is noted in almost all individuals exposed to microgravity

And still, their metabolism was working against them

Life Sci 2020

Glucocorticoids: The Most Clinically Significant Interaction Glucocorticoids (prednisone, dexamethasone, hydrocortisone, budesonide) blunt the GH response to GHRH stimulation through at least three mechanisms: they increase hypothalamic somatostatin tone, they directly reduce somatotroph sensitivity to GHRH, and they suppress hepatic IGF-1 production independent of GH